Functional analysis of the two reciprocal fusion genes MLL-NEBL and NEBL-MLL reveal their oncogenic potential.

doi:10.1016/j.canlet.2012.12.023

Article

Functional analysis of the two reciprocal fusion genes MLL-NEBL and NEBL-MLL reveal their oncogenic potential.

Cancer letters - 10 May 2013

Emerenciano Mariana, Kowarz Eric, Karl Katharina, de Almeida Lopes Bruno, Scholz Bastian, Bracharz Silvia, Meyer Claus, Pombo-de-Oliveira Maria S, Marschalek Rolf

Abstract excerpt

MLL gene aberrations are frequently diagnosed in infant acute myeloid leukemia (AML). We previously described the MLL-NEBL and NEBL-MLL genomic fusions in an infant AML patient with a chromosomal translocation t(10;11)(p12;q23). NEBL was the second Nebulin family member (LASP1, NEBL) which was found to be involved in MLL rearrangements. Here, we report on our attempts to unravel the oncogenic properties of both...

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