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Article

p300 activation by Presenilin 1 but not by its M146L mutant.

Neuroscience letters - 14 Feb 2007

Francis Yitshak I, Diss James K J, Kariti Moshe, Stephanou Anastasis, Latchman David S

Abstract excerpt

The transcriptional co-activator p300 plays an important role in regulating gene expression in a number of different cell types. We have shown that wild type (WT) Presenilin 1 (PS1) stimulates the transcriptional activity ability of CREB Binding Protein (CBP), a close homolog of p300, whereas the Alzheimer's disease (AD) associated mutant of PS1 does not have this effect. A recent report has suggested that mutant...

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Identifiers

PMID: 17197080
DOI: 10.1016/j.neulet.2006.11.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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