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Article

Nuclear Transcription Factor Kappa B Downregulation Reduces Chemoresistance in Bone Marrow-derived Cells Through P-glycoprotein Modulation.

Archives of medical research - 1 Feb 2016

Loaiza Brenda, Hernández-Gutierrez Salomon, Montesinos Juan Jose, Valverde Mahara, Rojas Emilio

Abstract excerpt

BACKGROUND AND AIMS: Nuclear transcription factor kappa B (NF-κB) is associated with many types of refractory cancer. However, despite multiple strategies to treat cancer and novel target drugs, multidrug resistance still causes relapses. The best-characterized mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein (P-gp). Because the direct inhibition of...

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Identifiers

PMID: 27259382
DOI: 10.1016/j.arcmed.2016.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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