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Article

Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome

10 Aug 2005

Abstract excerpt

Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency characterized by thrombocytopenia, eczema, and variable degrees of impaired cellular and humoral immunity. Age-dependent T-cell lymphopenia has been described in WAS, however, the diversity of the T-cell compartment over time in these patients has not been characterized. We have used complementarity-determining region 3 (CDR3) size distribution...

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PMID: 16091449
DOI: 10.1182/blood-2005-06-2336

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