Article
The spleen in the Wiskott-Aldrich syndrome: histopathologic abnormalities of the white pulp correlate with the clinical phenotype of the disease.
The American journal of surgical pathology - 1 Feb 1999
Vermi W, Blanzuoli L, Kraus M D, Grigolato P, Donato F, Loffredo G, Marino C E, Alberti D, Notarangelo L D, Facchetti F
Abstract excerpt
The Wiskott-Aldrich syndrome (WAS) is a X-linked hematologic disorder characterized by thrombocytopenia, eczema, and immunodeficiency of variable severity. Reported here are the results of a morphologic, morphometric, and immunophenotypic analysis of splenic lymphoid tissue in 12 WAS patients with documented molecular defect and with different disease severity. Spleens from 29 age-matched patients with different...
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