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Article

WASp Deficiency Selectively Affects the TCR Diversity of Different Memory T Cell Subsets in WAS Chimeric Mice.

Frontiers in immunology - 1 Jan 2021

Li Wenyan, Jia Yanjun, Wang Yanping, Zhao Qin, Yang Lu, Zeng Ting, Niu Linlin, Dai Rongxin, Li Yanan, Zhao Xiaodong, Wu Junfeng

Abstract excerpt

Background: The T cell receptor (TCR) diversity is essential for effective T cell immunity. Previous studies showed that TCR diversity in Wiskott-Aldrich Syndrome (WAS) patients was severely impaired, especially in the memory T cell populations. Whether this defect was caused by intrinsic WASp deficiency or extrinsic reasons is still unclear. Methods: We sorted different T cell subsets from the bone marrow...

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Identifiers

PMID: 35116029
DOI: 10.3389/fimmu.2021.794795
PMCID: PMC8803657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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