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Article

Identity elements of human tRNA(Leu): structural requirements for converting human tRNA(Ser) into a leucine acceptor in vitro.

Nucleic acids research - 25 Sept 1995

Breitschopf K, Achsel T, Busch K, Gross H J

Abstract excerpt

We have previously shown that the exchange of the discriminator base A73 of human tRNA(Leu) for G is alone sufficient to achieve complete loss of leucine acceptance and to create an efficient serine acceptor. The reverse identity switch, however, which was studied using T7 RNA polymerase transcripts of in vitro mutagenized tRNA genes, reveals a far more complex pattern of identity elements for tRNA(Leu)....

Topics

Acylation
Base Sequence
Humans
Kinetics
Leucine
Leucine-tRNA Ligase
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA, Transfer, Leu
RNA, Transfer, Ser

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Deletion

Serine-tRNA Ligase

Substrate Specificity

Source

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Identifiers

PMID: 7478989
DOI: 10.1093/nar/23.18.3633
PMCID: PMC307258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7478989-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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