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Article

Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2005

Balhoff James P, Wray Gregory A

Abstract excerpt

The evolutionary mechanisms that operate on genetic variation within transcriptional regulatory sequences are not well understood. We present here an evolutionary analysis of an exceptionally well characterized cis-regulatory region, the endo16 promoter of the purple sea urchin. Segregating variation reveals striking differences in the intensity of negative selection among regulatory modules, reflecting their...

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PMID: 15937122
DOI: 10.1073/pnas.0409638102
PMCID: PMC1150811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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