Article
Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
Human molecular genetics - 15 Sept 2005
Winrow Christopher J, Pankratz Daniel G, Vibat Cecile Rose T, Bowen T J, Callahan Marie A, Warren Amy J, Hilbush Brian S, Wynshaw-Boris Anthony, Hasel Karl W, Weaver Zoë, Lockhart David J, Barlow Carrolee
Abstract excerpt
Ataxia telangiectasia (A-T) is an autosomal recessive disease caused by loss of function of the serine/threonine protein kinase ATM (ataxia telangiectasia mutated). A-T patients have a 250-700-fold increased risk of developing lymphomas and leukemias which are typically highly invasive and proliferative. In addition, a subset of adult acute lymphoblastic leukemias and aggressive B-cell chronic lymphocytic...
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