Article
The effect of charge reversal mutations in the alpha-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids.
Molecular and cellular biochemistry - 1 Oct 2002
Hagan Robert M, Davies Joanna K, Wilton David C
Abstract excerpt
Liver fatty acid binding protein (LFABP) is unique among the various types of FABPs in that it can bind a variety of ligands in addition to fatty acids. LFABP is able to bind long chain fatty acids with a 2:1 stoichiometry and the crystal structure has identified two fatty acid binding sites in the binding cavity. The presumed primary site (site 1) involves the fatty acid binding with the carboxylate group buried...
Topics
- Acyl Coenzyme A
- Animals
- Bile Acids and Salts
- Carrier Proteins
- Fatty Acid-Binding Protein 7
- Fatty Acid-Binding Proteins
- Fatty Acids
- Lysophospholipids
- Models, Molecular
- Mutation
- Neoplasm Proteins
- Nerve Tissue Proteins
- Protein Binding
- Protein Structure, Secondary
- Rats