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aFGF gene-modified adipose-derived mesenchymal stem cells promote healing of full-thickness skin defects in diabetic rats

25 Feb 2025

Abstract excerpt

Chronic diabetic wounds pose a significant clinical challenge due to the limited efficacy of current treatments. This study aimed to investigate the role and potential mechanisms of adipose-derived mesenchymal stem cells (ADSCs) overexpressing acidic fibroblast growth factor (aFGF) in diabetic wound healing in a rat model. ADSCs were genetically modified to achieve stable overexpression of aFGF. Varying doses of...

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Share to Diabetic Foot Ulcer Assessment and Management
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PMID: 40001190
DOI: 10.1186/s13287-025-04241-5

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