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Article

Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (Drosophila Chk1).

Journal of cell science - 1 Aug 2005

Purdy Amanda, Uyetake Lyle, Cordeiro Melissa Garner, Su Tin Tin

Abstract excerpt

Checkpoints monitor the state of DNA and can delay or arrest the cell cycle at multiple points including G1-S transition, progress through S phase and G2-M transition. Regulation of progress through mitosis, specifically at the metaphase-anaphase transition, occurs after exposure to ionizing radiation (IR) in Drosophila and budding yeast, but has not been conclusively demonstrated in mammals. Here we report that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16079276
DOI: 10.1242/jcs.02454
PMCID: PMC3242735

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