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Article

Platelet characteristics change with aging: role of estrogen receptor beta.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jul 2005

Jayachandran Muthuvel, Karnicki Krzysztof, Miller Randall S, Owen Whyte G, Korach Kenneth S, Miller Virginia M

Abstract excerpt

Estrogen receptor beta (betaER) is the predominant estrogen receptor in platelets. Experiments were designed to define phenotypic changes in platelets with aging following deletion of betaER (betaERKO). Blood was collected from wild-type and betaERKO female mice at 4-7 (young) and 24-25 (aged) months of age. In young animals, total number of platelets, number of platelets containing RNA (reticulated platelets),...

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Identifiers

PMID: 16079202
DOI: 10.1093/gerona/60.7.815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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