Article
High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children.
BMC infectious diseases - 31 May 2010
Holt Kathryn E, Baker Stephen, Dongol Sabina, Basnyat Buddha, Adhikari Neelam, Thorson Stephen, Pulickal Anoop S, Song Yajun, Parkhill Julian, Farrar Jeremy J, Murdoch David R, Kelly Dominic F, Pollard Andrew J, Dougan Gordon
Abstract excerpt
BACKGROUND: Salmonella Typhi (S. Typhi) causes typhoid fever, which remains an important public health issue in many developing countries. Kathmandu, the capital of Nepal, is an area of high incidence and the pediatric population appears to be at high risk of exposure and infection. METHODS: We recently defined the population structure of S. Typhi, using new sequencing technologies to identify nearly 2,000 single...
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