Article
The cystic fibrosis heterozygote--advantage in surviving cholera?
Medical hypotheses - 1 Nov 1991
Rodman D M, Zamudio S
Abstract excerpt
Cystic fibrosis (CF) is the most common fatal genetic disorder of caucasians. While it has been hypothesized that there is a CF heterozygote advantage which allowed the gene to achieve such high prevalence, the nature of that advantage remains a mystery. The recent identification and sequencing of the CF gene has increased the probability that the CF heterozygote advantage will be discovered. In this hypothesis...
Topics
- Chloride Channels
- Chlorides
- Cholera
- Cystic Fibrosis
- Heterozygote
- Humans
- Ion Channels
- Membrane Proteins
- Models, Biological
- Mutation