Article
Role of epicardial mesothelial cells in the modification of phenotype and function of adult rat ventricular myocytes in primary coculture.
Circulation research - 1 Jul 1992
Eid H, Larson D M, Springhorn J P, Attawia M A, Nayak R C, Smith T W, Kelly R A
Abstract excerpt
Adult rat ventricular myocytes undergo a well-documented sequence of phenotypic changes during adaptation to primary culture. However, we observed that coculture of myocytes with a specific subset of nonmyocyte cardiac cells could slow and even reverse the process of adaptation. These nonmyocyte cells were isolated and identified by immunohistochemical and ultrastructural criteria as being of epicardial...
Topics
- Animals
- Cells, Cultured
- Cytological Techniques
- Epithelial Cells
- Epithelium
- Heart
- Heart Ventricles
- Myocardium
- Pericardium
- Phenotype
- Rats