Article
Adult rat ventricular myocytes cultured in defined medium: phenotype and electromechanical function.
The American journal of physiology - 1 Aug 1993
Ellingsen O, Davidoff A J, Prasad S K, Berger H J, Springhorn J P, Marsh J D, Kelly R A, Smith T W
Abstract excerpt
We studied primary short-term cultures of adult rat ventricular myocytes in defined medium to determine whether phenotype and electromechanical function are maintained in rod-shaped, quiescent cells. Although > 80% of the myocytes retained their rod-shaped in vivo morphology for up to 72 h, contractile function as measured by cell edge motion declined 30-50% from 6 to 24 h, paralleling a 68% shortening of action...
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