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Article

NKX3.1 activates cellular response to DNA damage.

Cancer research - 15 Apr 2010

Bowen Cai, Gelmann Edward P

Abstract excerpt

The prostate-specific tumor suppressor homeodomain protein NKX3.1 is inactivated by a variety of mechanisms in the earliest phases of prostate carcinogenesis and in premalignant regions of the prostate gland. The mechanisms by which NKX3.1 exercises tumor suppression have not been well elucidated. Here, we show that NKX3.1 affects DNA damage response and cell survival after DNA damage. NKX3.1 expression in PC-3...

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Source

Identifiers

PMID: 20395202
DOI: 10.1158/0008-5472.CAN-09-3138

Genes

ATM
ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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