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Article

Mice lacking the p53/p63 target gene Perp are resistant to papilloma development.

Cancer research - 1 Aug 2005

Marques Michelle R, Horner Jennifer S, Ihrie Rebecca A, Bronson Roderick T, Attardi Laura D

Abstract excerpt

Perp is a target of the p53 tumor suppressor involved in the DNA damage-induced apoptosis pathway. In addition, Perp is a target of the p53-related transcription factor p63 during skin development, where it participates in cell-cell adhesion mediated through desmosomes. Here we test the role of Perp in tumorigenesis in a two-step skin carcinogenesis model system. We find that mice lacking Perp in the skin are...

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Identifiers

PMID: 16061634
DOI: 10.1158/0008-5472.CAN-05-0366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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