Article
Effects of TP63 mutations on keratinocyte adhesion and migration.
Experimental dermatology - 1 Sept 2023
Salois Maddison N, Gugger Jessica A, Webb Saiphone, Sheldon Christina E, Parraga Shirley P, Lewitt G Michael, Grange Dorothy K, Koch Peter J, Koster Maranke I
Abstract excerpt
The goal of this study was to investigate the molecular mechanisms responsible for the formation of skin erosions in patients affected by Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC). This ectodermal dysplasia is caused by mutations in the TP63 gene, which encodes several transcription factors that control epidermal development and homeostasis. We generated induced pluripotent stem cells...
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