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Article

Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.

The Journal of biological chemistry - 14 Oct 2005

Lee Nathan V, Rodriguez-Manzaneque Juan Carlos, Thai Shelley N-M, Twal Waleed O, Luque Alfonso, Lyons Karen M, Argraves W Scott, Iruela-Arispe M Luisa

Abstract excerpt

ADAMTS-1 is a metalloprotease that has been implicated in the inhibition of angiogenesis and is a mediator of proteolytic cleavage of the hyaluronan binding proteoglycans, aggrecan and versican. In an attempt to further understand the biological function of ADAMTS-1, a yeast two-hybrid screen was performed using the carboxyl-terminal region of ADAMTS-1 as bait. As a result, the extracellular matrix protein...

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Identifiers

PMID: 16061471
DOI: 10.1074/jbc.M506980200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.PMID 16061471Read ↗

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New Insights into ADAMTS Metalloproteases in the Central Nervous SystemSemantic proximity Read ↗

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