Article
Identification of an unconventional nuclear localization signal in human ribosomal protein S2.
Biochemical and biophysical research communications - 16 Sept 2005
Antoine M, Reimers K, Wirz W, Gressner A M, Müller R, Kiefer P
Abstract excerpt
Ribosomal proteins must be imported into the nucleus after being synthesized in the cytoplasm. Since the rpS2 amino acid sequence does not contain a typical nuclear localization signal, we used deletion mutant analysis and rpS2-beta-galactosidase chimeric proteins to identify the nuclear targeting domains in rpS2. Nuclear rpS2 is strictly localized in the nucleoplasm and is not targeted to the nucleoli....
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