Expression of MDR1 and GST-pi in human soft tissue sarcomas: relation to drug resistance and biological aggressiveness.

doi:10.1093/oxfordjournals.annonc.a058073

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Article

Expression of MDR1 and GST-pi in human soft tissue sarcomas: relation to drug resistance and biological aggressiveness.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 1992

Toffoli G, Frustaci S, Tumiotto L, Talamini R, Gherlinzoni F, Picci P, Boiocchi M

Abstract excerpt

Human soft tissue sarcomas (HSTS) in adults are a family of mesenchymal tumors characterized by high biological aggressiveness and general refractoriness to chemotherapy. A series of 36 HSTS, 24 untreated and 12 homogeneously treated with a presurgical chemotherapeutic regimen consisting of doxorubicin (intra-arterial) and iphosphamide (intra-vein), was analyzed for expression of MDR1 and the...

Topics

Adult
Aged
Aged, 80 and over
DNA
Drug Resistance
Female
Flow Cytometry
Gene Expression
Glutathione Transferase
Histones
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Male

Middle Aged

Phenotype

RNA, Messenger

Sarcoma

Soft Tissue Neoplasms

Source

Open in PubMed

Identifiers

PMID: 1606072
DOI: 10.1093/oxfordjournals.annonc.a058073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1606072-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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