Article
Age at onset of schizophrenia: interaction between brain-derived neurotrophic factor and dopamine D3 receptor gene variants.
Neuroreport - 22 Aug 2005
Gourion David, Goldberger Celine, Leroy Sophie, Bourdel Marie-Chantal, Olié Jean-Pierre, Krebs Marie-Odile
Abstract excerpt
One of the main features of schizophrenia is its age at onset in early adulthood. Dopaminergic dysregulation is the most documented neurobiological factor that may be involved in triggering schizophrenia. Recent findings on neurodevelopmental processes show that the brain-derived neurotrophic factor plays a critical role in the development of mesolimbic dopaminergic-related systems and regulates the expression of...
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