Article
Identification of a crucial site for synoviolin expression.
Molecular and cellular biology - 1 Aug 2005
Tsuchimochi Kaneyuki, Yagishita Naoko, Yamasaki Satoshi, Amano Tetsuya, Kato Yukihiro, Kawahara Ko-ichi, Aratani Satoko, Fujita Hidetoshi, Ji Fengyun, Sugiura Akiko, Izumi Toshihiko, Sugamiya Asako, Maruyama Ikuro, Fukamizu Akiyoshi, Komiya Setsuro, Nishioka Kusuki, Nakajima Toshihiro
Abstract excerpt
Synoviolin is an E3 ubiquitin ligase localized in the endoplasmic reticulum (ER) and serving as ER-associated degradation system. Analysis of transgenic mice suggested that synoviolin gene dosage is implicated in the pathogenesis of arthropathy. Complete deficiency of synoviolin is fatal embryonically. Thus, alternation of Synoviolin could cause breakdown of ER homeostasis and consequently lead to disturbance of...
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