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Article

SK3 channel expression during pregnancy is regulated through estrogen and Sp factor-mediated transcriptional control of theKCNN3gene

4 Aug 2010

Abstract excerpt

Overexpression of the small-conductance calcium-activated K(+) channel 3 (SK3) in transgenic mice compromises parturition, suggesting that the SK3 channel plays a role in pregnancy. In wild-type mouse myometrium, expression of SK3 transcript and protein is significantly reduced during pregnancy, but the mechanism(s) responsible for this attenuation of channel expression is unknown. The promoter region of the...

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PMID: 20682843
DOI: 10.1152/ajpendo.00063.2010

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