The Roles of Synoviolin in Crosstalk Between Endoplasmic Reticulum Stress-Induced Apoptosis and p53 Pathway

Abstract excerpt

Endopalsmic reticulum (ER) is specialized organelle to maintain the integrity of secreted and membranous proteins. ER also senses so-called "ER stress", which is a result of various internal and external stresses, and triggers apoptosis when the diverse attempts to accommodate with the stress are in fail. The impairment these ER functions has been implicated in several human diseases, in which aberrant ER stress...

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