Cell culture propagation modifies the African swine fever virus replication phenotype in macrophages and generates viral subpopulations differing in protein p54.

doi:10.1016/0168-1702(92)90076-l

Article

Cell culture propagation modifies the African swine fever virus replication phenotype in macrophages and generates viral subpopulations differing in protein p54.

Virus research - 1 Apr 1992

Alcaraz C, Brun A, Ruiz-Gonzalvo F, Escribano J M

Abstract excerpt

We have detected 86 African swine fever (ASF) virus-induced proteins in infected pig macrophages by two-dimensional electrophoresis. No differences among protein patterns of wild-type viruses could be observed by this methodology. However, during cell culture adaptation and propagation we have ch...

Topics

African Swine Fever
African Swine Fever Virus
Animals
Cells, Cultured
Electrophoresis, Gel, Two-Dimensional
Genetic Variation
Macrophages
Phenotype
Swine
Viral Proteins
Virulence
Virus Replication

Cell culture propagation modifies the African swine fever virus replication phenotype in macrophages and generates viral subpopulations differing in protein p54.

Abstract excerpt

Topics

Discuss the evidence