Article
The progressive adaptation of a georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major modifications of the viral genome.
Journal of virology - 1 Feb 2015
Krug Peter W, Holinka Lauren G, O'Donnell Vivian, Reese Bo, Sanford Brenton, Fernandez-Sainz Ignacio, Gladue Douglas P, Arzt Jonathan, Rodriguez Luis, Risatti Guillermo R, Borca Manuel V
Abstract excerpt
UNLABELLED: African swine fever virus (ASFV) causes a contagious and often lethal disease of feral and domestic swine. Experimental vaccines derived from naturally occurring, genetically modified, or cell culture-adapted ASFV have been evaluated, but no commercial vaccine is available to control African swine fever (ASF). We report here the genotypic and phenotypic analysis of viruses obtained at different...
Topics
- Adaptation, Biological
- African Swine Fever Virus
- Animals
- Cells, Cultured
- Chlorocebus aethiops
- DNA, Viral
- Genome, Viral
- Genotype
- Georgia (Republic)