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Article

Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans.

Development (Cambridge, England) - 1 Sept 2005

Zhu Xianjun, Sen Jonaki, Stevens Leslie, Goltz Jason S, Stein David

Abstract excerpt

The Drosophila pipe gene encodes ten related proteins that exhibit amino acid sequence similarity to vertebrate heparan sulfate 2-O-sulfotransferase. One of the Pipe isoforms, which is expressed in the ventral follicular epithelium, is a key determinant of embryonic dorsoventral polarity, suggesting that Pipe-mediated sulfation of a heparan sulfate proteoglycan provides a spatial cue for dorsoventral axis...

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Identifiers

PMID: 16049108
DOI: 10.1242/dev.01962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans.PMID 16049108Read ↗

The Drosophila dorsoventral determinant PIPE contains ten copies of a variable domain homologous to mammalian heparan sulfate 2-sulfotransferase.Semantic proximity Read ↗

Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe.Semantic proximity Read ↗

Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity.Semantic proximity Read ↗

Synthesis of the sulfate donor PAPS in either the Drosophila germline or somatic follicle cells can support embryonic dorsal-ventral axis formation.Semantic proximity Read ↗

No requirement for localized Nudel protein expression in Drosophila embryonic axis determination.Semantic proximity Read ↗

Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.Semantic proximity Read ↗

Windbeutel is required for function and correct subcellular localization of the Drosophila patterning protein Pipe.Semantic proximity Read ↗

Localized requirements for windbeutel and pipe reveal a dorsoventral prepattern within the follicular epithelium of the Drosophila ovary.Semantic proximity Read ↗

Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.Semantic proximity Read ↗

Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans.Semantic proximity Read ↗

Mosaic analyses reveal the function of Drosophila Ras in embryonic dorsoventral patterning and dorsal follicle cell morphogenesis.Semantic proximity Read ↗

Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans.Semantic proximity Read ↗

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