Article
Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study.
Human molecular genetics - 15 Sept 2005
Frisdal Eric, Klerkx Anke H E M, Le Goff Wilfried, Tanck Michael W T, Lagarde Jean-Pierre, Jukema J Wouter, Kastelein John J P, Chapman M John, Guerin Maryse
Abstract excerpt
Cholesteryl ester transfer protein (CETP) plays a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism. The TaqIB polymorphism of the CETP gene is associated with plasma CETP and high-density lipoprotein cholesterol (HDL-C) levels and with premature coronary artery disease. Such associations appear to result from linkage disequilibrium between TaqIB...
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