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Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis.

Microbial drug resistance (Larchmont, N.Y.) - 1 Apr 2012

Sirgel Frederick A, Tait Marisa, Warren Robin M, Streicher Elizabeth M, Böttger Erik C, van Helden Paul D, Gey van Pittius Nicolaas C, Coetzee Gerrit, Hoosain Ebrahim Y, Chabula-Nxiweni Mamisa, Hayes Cindy, Victor Thomas C, Trollip André

Abstract excerpt

The aminoglycosides amikacin (AMK)/kanamycin (KAN) and the cyclic polypeptide capreomycin (CAP) are important injectable drugs in the treatment of multidrug-resistant tuberculosis. Cross-resistance among these drug classes occurs and information on the minimum inhibitory concentrations (MICs), above the normal wild-type distribution, may be useful in identifying isolates that are still accessible to drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21732736
DOI: 10.1089/mdr.2011.0063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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