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Article

Functional analysis of biologically distinct genetic variants of simian immunodeficiency virus isolated from a mandrill.

Virology - 1 Jul 1992

Sakai H, Sakuragi J, Sakuragi S, Shibata R, Adachi A

Abstract excerpt

We examined the biological properties of two infectious clones of a simian immunodeficiency virus, SIVMND, which were designated as pMD121 and pMD122. Upon transfection into CD4-negative cells, pMD122 generated virions much less efficiently than pMD121. Likewise, the growth kinetics in CD4-positive cells of virus derived from pMD122 were remarkably delayed relative to those of virus from pMD121. The cytocidal...

Topics

Amino Acid Sequence
Animals
CD4 Antigens
Chromosome Mapping
Cloning, Molecular
Exons
Genes, env
Genes, rev
Genes, tat
Genetic Variation
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Papio

Phenotype

Simian Immunodeficiency Virus

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 1604807
DOI: 10.1016/0042-6822(92)90691-h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1604807-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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