Article
Polyphosphate kinase regulates error-prone replication by DNA polymerase IV in Escherichia coli.
Molecular microbiology - 1 Aug 2005
Stumpf Jeffrey D, Foster Patricia L
Abstract excerpt
The ppk gene encodes polyphosphate kinase (Ppk), an enzyme that catalyses the polymerization of inorganic phosphate into long chains of polyphosphate (polyP). An insertion mutation in ppk causes a decrease in adaptive mutation in Escherichia coli strain FC40. Adaptive mutation in FC40 mostly results from error-prone DNA polymerase IV (Pol IV), encoded by dinB; most of the antimutagenic phenotype of the ppk mutant...
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