Article
Multi-level evaluation of Escherichia coli polyphosphate related mutants using global transcriptomic, proteomic and phenomic analyses.
Biochimica et biophysica acta. General subjects - 1 Apr 2017
Varas Macarena, Valdivieso Camilo, Mauriaca Cecilia, Ortíz-Severín Javiera, Paradela Alberto, Poblete-Castro Ignacio, Cabrera Ricardo, Chávez Francisco P
Abstract excerpt
BACKGROUND: Polyphosphate (polyP) is a linear biopolymer found in all living cells. In bacteria, mutants lacking polyphosphate kinase 1 (PPK1), the enzyme responsible for synthesis of most polyP, have many structural and functional defects. However, little is known about the causes of these pleiotropic alterations. The link between ppk1 deletion and those numerous phenotypes observed can be the result of complex...
Topics
- Antitoxins
- Bacterial Proteins
- Cell Respiration
- Escherichia coli
- Escherichia coli Proteins
- Fermentation
- Metabolic Networks and Pathways
- Mutation
- Phosphotransferases (Alcohol Group Acceptor)
- Polyphosphates
- Proteome
- Proteomics