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Article

Metabolic ratios of psychotropics as indication of cytochrome P450 2D6/2C19 genotype.

Therapeutic drug monitoring - 1 Aug 2005

van der Weide Jan, van Baalen-Benedek Erica H, Kootstra-Ros Jenny E

Abstract excerpt

The cytochrome P450 enzymes (CYP) 2C19 and 2D6 are involved in the metabolism of many psychotropic drugs. Variability in enzyme activity results in variable metabolic capacities, affecting the metabolism of substrates. The metabolic ratio (MR) of drugs metabolized via these enzymes may therefore reflect the enzyme's activity and/or genotype. To serve as an example for different groups of medications, the...

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Identifiers

PMID: 16044105
DOI: 10.1097/01.ftd.0000162868.84596.c3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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