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Article

Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.

Infection and immunity - 1 Aug 2005

Bignell Elaine, Negrete-Urtasun Susana, Calcagno Ana Maria, Arst Herbert N, Rogers Tom, Haynes Ken

Abstract excerpt

While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47(phox)(-/-) mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent p-aminobenzoate auxotroph. This demonstrates that p47(phox)(-/-) murine immunity contributes...

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Identifiers

PMID: 16041040
DOI: 10.1128/IAI.73.8.5204-5207.2005
PMCID: PMC1201179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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