Article
NMD microarray analysis for rapid genome-wide screen of mutated genes in cancer.
Cellular oncology : the official journal of the International Society for Cellular Oncology - 1 Jan 2005
Wolf Maija, Edgren Henrik, Muggerud Aslaug, Kilpinen Sami, Huusko Pia, Sørlie Therese, Mousses Spyro, Kallioniemi Olli
Abstract excerpt
Gene mutations play a critical role in cancer development and progression, and their identification offers possibilities for accurate diagnostics and therapeutic targeting. Finding genes undergoing mutations is challenging and slow, even in the post-genomic era. A new approach was recently developed by Noensie and Dietz to prioritize and focus the search, making use of nonsense-mediated mRNA decay (NMD)...
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