Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer.

doi:10.1038/ng1408

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Article

Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer.

Nature genetics - 1 Sept 2004

Huusko Pia, Ponciano-Jackson Damaris, Wolf Maija, Kiefer Jeff A, Azorsa David O, Tuzmen Sukru, Weaver Don, Robbins Christiane, Moses Tracy, Allinen Minna, Hautaniemi Sampsa, Chen Yidong, Elkahloun Abdel, Basik Mark, Bova G Steven, Bubendorf Lukas, Lugli Alessandro, Sauter Guido, Schleutker Johanna, Ozcelik Hilmi, Elowe Sabine, Pawson Tony, Trent Jeffrey M, Carpten John D, Kallioniemi Olli-P, Mousses Spyro

Abstract excerpt

The identification of tumor-suppressor genes in solid tumors by classical cancer genetics methods is difficult and slow. We combined nonsense-mediated RNA decay microarrays and array-based comparative genomic hybridization for the genome-wide identification of genes with biallelic inactivation involving nonsense mutations and loss of the wild-type allele. This approach enabled us to identify previously unknown...

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PMID: 15300251
DOI: 10.1038/ng1408

Genes

EPHB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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