Article
The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases - 1 Jun 2005
Achilli Francesca, Boyle Shelagh, Kieran Dairin, Chia Ruth, Hafezparast Majid, Martin Joanne E, Schiavo Giampietro, Greensmith Linda, Bickmore Wendy, Fisher Elizabeth M C
Abstract excerpt
The SOD1G93A transgenic mouse strain which carries a human mutant Cu/Zn superoxide dismutase transgene array is a widely studied model of amyotrophic lateral sclerosis. These mice have been used in many breeding experiments to look for interactions with other loci, including transgenic and gene targeted mutations. Therefore, we decided to map the site of the transgene insertion as this may affect the outcome of...
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