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Article

Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS.

Brain research. Molecular brain research - 4 Nov 2004

Alexander Guillermo M, Erwin Kirsten L, Byers Nathaniel, Deitch Jeffrey S, Augelli Brian J, Blankenhorn Elizabeth P, Heiman-Patterson Terry D

Abstract excerpt

Transgenic mice expressing multiple copies of the G93A mutant form of SOD1 develop motor neuron pathology and clinical symptoms similar to those seen in patients with amyotrophic lateral sclerosis (ALS). The phenotype of these mice is dependent on the number of transgene copies in their genome. Changes in transgene copy number, although rare, can sometimes occur while mating due to intra locus recombination...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15519671
DOI: 10.1016/j.molbrainres.2004.07.002

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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