Article
From bases to basis: linking genetics to causation in primary biliary cirrhosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 May 2005
Invernizzi Pietro, Selmi Carlo, Mackay Ian R, Podda Mauro, Gershwin M Eric
Abstract excerpt
Primary biliary cirrhosis (PBC) is a multifactorial autoimmune disease with inherited and environmental components in pathogenesis. It is exceptional among autoimmune diseases in showing strong heritability according to familial occurrence and monozygotic twins concordance, yet with weak associations with the usual genetic risk elements for autoimmunity, such as the HLA alleles. Among the latter, there is risk...
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