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Article

Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines

1 Apr 2009

Abstract excerpt

The tumor-associated Tn antigen has been investigated extensively as a biomarker and therapeutic target. Cancer vaccines containing the Tn antigen as a single tumor antigen or as a component of a polyvalent vaccine have progressed into phase I and II clinical trials. One major focus of Tn-based vaccines is the treatment of prostate cancer patients. Although expression of the antigen on prostate tumors is a...

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PMID: 19372570
DOI: 10.1158/1535-7163.mct-08-0934

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