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Article

Functional Analyses of Mutations in Receptor Tyrosine Kinase Genes in Non-Small Cell Lung Cancer: Double-Edged Sword of DDR2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2016

Terashima Masato, Togashi Yosuke, Sato Katsuaki, Mizuuchi Hiroshi, Sakai Kazuko, Suda Kenichi, Nakamura Yu, Banno Eri, Hayashi Hidetoshi, De Velasco Marco A, Fujita Yoshihiko, Tomida Shuta, Mitsudomi Tetsuya, Nishio Kazuto

Abstract excerpt

PURPOSE: This study investigated whether mutations of receptor tyrosine kinase (RTK) genes detected using next-generation sequencing (NGS) are suitable therapeutic targets. EXPERIMENTAL DESIGN: Fifty surgically resected non-small cell lung cancer (NSCLC) samples were target resequenced using NGS. We then investigated the functions of the identified RTK gene mutations, including their oncogenic potential, in vitro...

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Source

Identifiers

PMID: 26826182
DOI: 10.1158/1078-0432.CCR-15-2093

Genes

DDR2
ERBB4
FGFR1
ALK
BRAF
EGFR
KRAS
NRAS
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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