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Article

The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism.

Biological psychiatry - 1 Nov 2005

Willis-Owen Saffron A G, Fullerton Jan, Surtees Paul G, Wainwright Nick W J, Miller Susette, Flint Jonathan

Abstract excerpt

BACKGROUND: The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness. METHODS: Here we report an attempt to replicate this association using three populations of extreme neuroticism scorers derived from two large English cohorts (n = 88,142 and n = 20,921). On...

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Source

Identifiers

PMID: 16043130
DOI: 10.1016/j.biopsych.2005.05.014

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism.PMID 16043130Read ↗

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