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Article

Tumor necrosis factor-α inhibits hTERT gene expression in human myeloid normal and leukemic cells

15 Jul 2005

Abstract excerpt

Telomerase catalytic subunit (hTERT) has been shown to play a critical role not only in telomere homeostasis but also in cellular survival, DNA repair, and genetic stability. In a previous study, we described that tumor necrosis factor-xalpha (TNFxalpha) induced in the leukemic KG1 cells a senescence state characterized by decreased hTERT activity followed by prolonged growth arrest, increasedx beta-galactosidase...

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PMID: 16020509
DOI: 10.1182/blood-2005-04-1386

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