Interleukin-1 beta induction of tumor necrosis factor-alpha gene expression in human astroglioma cells.

doi:10.1016/0165-5728(92)90049-q

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Article

Interleukin-1 beta induction of tumor necrosis factor-alpha gene expression in human astroglioma cells.

Journal of neuroimmunology - 1 Feb 1992

Bethea J R, Chung I Y, Sparacio S M, Gillespie G Y, Benveniste E N

Abstract excerpt

Cells that produce tumor necrosis factor-alpha (TNF-alpha) require the presence of signaling molecules since this cytokine is not normally expressed in a constitutive manner. It has been demonstrated that glial cells can produce TNF-alpha; however, the specific inducing molecules and their mechan...

Topics

Astrocytoma
Cycloheximide
Gene Expression
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Interleukin-1
Phenotype
RNA, Messenger
Transcription, Genetic
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha

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