Article
A method of mapping protein sumoylation sites by mass spectrometry using a modified small ubiquitin-like modifier 1 (SUMO-1) and a computational program.
Molecular & cellular proteomics : MCP - 1 Oct 2005
Knuesel Matthew, Cheung Hiu Tom, Hamady Micah, Barthel Kristen K B, Liu Xuedong
Abstract excerpt
Post-translational modification by small ubiquitin-like modifier 1 (SUMO-1) is a highly conserved process from yeast to humans and plays important regulatory roles in many cellular processes. Sumoylation occurs at certain internal lysine residues of target proteins via an isopeptide bond linkage. Unlike ubiquitin whose carboxyl-terminal sequence is RGG, the tripeptide at the carboxyl terminus of SUMO is TGG. The...
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