Article
Proteome-wide identification of SUMO2 modification sites.
Science signaling - 29 Apr 2014
Tammsalu Triin, Matic Ivan, Jaffray Ellis G, Ibrahim Adel F M, Tatham Michael H, Hay Ronald T
Abstract excerpt
Posttranslational modification with small ubiquitin-like modifiers (SUMOs) alters the function of proteins involved in diverse cellular processes. SUMO-specific enzymes conjugate SUMOs to lysine residues in target proteins. Although proteomic studies have identified hundreds of sumoylated substrates, methods to identify the modified lysines on a proteomic scale are lacking. We developed a method that enabled...
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