IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis.

doi:10.1371/journal.pone.0046017

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Article

IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis.

PloS one - 1 Jan 2012

Zhang Ying, Liu Changming, Peng Huiping, Zhang Jianzhi, Feng Quanlin

Abstract excerpt

IL1 receptor antagonist (IL1RA) and IL1beta (IL1β), members of the pro-inflammatory cytokine interleukin-1 (IL1) family, play a potential role against infection and in the pathogenesis of cancers. The variable number of tandem repeats (VNTR) polymorphism in the second intron of the IL1 receptor antagonist gene (IL1-RN) and a polymorphism in exon 5 of IL1B (IL1B+3954C>T, rs1143634) have been suggested in...

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PMID: 23049925
DOI: 10.1371/journal.pone.0046017
PMCID: PMC3457944

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